Amiodarone-digoxin interaction: clinical significance, time course of development, potential pharmacokinetic mechanisms and therapeutic implications.

@article{Nademanee1984AmiodaronedigoxinIC,
  title={Amiodarone-digoxin interaction: clinical significance, time course of development, potential pharmacokinetic mechanisms and therapeutic implications.},
  author={Koonlawee Nademanee and Ravi Kannan and John A Hendrickson and Murad Ookhtens and I Kay and Bramah N. Singh},
  journal={Journal of the American College of Cardiology},
  year={1984},
  volume={4 1},
  pages={111-6}
}
Administration of amiodarone (600 to 1,600 mg/day) to 28 patients during long-term digoxin therapy (0.25 +/- 0.05 mg/day) increased serum digoxin level from 0.97 +/- 0.45 to 1.98 +/- 0.84 ng/ml (p less than 0.001). Gastrointestinal side effects occurred in nine patients, central nervous system reactions occurred in five and cardiovascular reactions occurred in four. Pharmacokinetic studies in six patients with a 1 mg intravenous digoxin dose before and during amiodarone therapy increased serum… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
21 Extracted Citations
27 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 21 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 27 references

Arniodarone-digoxin interaction during treatment of resistant cardiac arrhythmias (abstr)

  • K Nademanee, R Kannan, JA Hendrickson, M Burnam, 1 Kay, BN. Singh
  • Am J Cardiol
  • 1982

Evidence for involvement of an extrarenal mechanism

  • F Steiness
  • Eur J Clin Pharmacol
  • 1982

The influence of verapamil on serum digoxin concentration

  • HD Klein, R Land, E Weiss
  • Circulation
  • 1982

Similar Papers

Loading similar papers…