Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage.

@article{Hwu2004AminylAI,
  title={Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage.},
  author={Jih Ru Hwu and Chun Chieh Lin and Shih Hsien Chuang and Ke Yung King and Tzu-rong Su and Shwu-Chen Tsay},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 10},
  pages={2509-15}
}
Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N*) and iminyl (R2C=N*) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350 nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular phiX174 RFI DNA at pH 6.0 resulted in single-strand cleavage of DNA. Attachment of the… CONTINUE READING

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