Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53

@article{Mann2005AminothiolWI,
  title={Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53},
  author={Kristine Mann and Pierre Hainaut},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={3964-3975}
}
The aminothiol WR1065 exerts selective cytoprotective effects in normal cells compared to cancer cells and has clinical applications for the protection of normal cells in cancer patients undergoing radio- or chemotherapy. There is evidence that p53 is activated in response to WR1065. To examine the effects of WR1065 on the signalling pathways controlled by p53, isogeneic human colon carcinoma cell lines (HCT116) differing only in the presence or absence of wild-type p53 were used. Treatment… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

S100 family signaling network and related proteins in pancreatic cancer (Review).

International journal of molecular medicine • 2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Antioxid

P Hainaut, K. Mann
Redox Signal., 3, 611–623. • 2001
View 4 Excerpts
Highly Influenced

Br

EJ Lee, M Gerhold, MW Palmer, RD. Christen
J. Cancer, 88, 754–759. • 2003

Int

Y Kataoka, JS Murley, NN Khodarev, RR Weichselbaum, DJ. Grdina
J. Radiat. Oncol. Biol. Phys., 53, 180–189. • 2002

J

H Shen, ZJ Chen, +3 authors KD. Tew
Pharmacol. Exp. Ther., 297, 1067–1073. • 2001

Proc

M Tan, Y Wang, K Guan, Y. Sun
Natl. • 2000

Eur

Capizzi RL.
J. Cancer, 32A (Suppl 4), S5–S16. • 1996

Mol

R Rainwater, D Parks, ME Anderson, P Tegtmeyer, K. Mann
Cell. Biol., 15, 3892–3903. • 1995

Cancer Chemother

EA Poplin, P LoRusso, +7 authors P. Schein
Pharmacol., 33, 415–419. • 1994

Biochem

BS Polla, Y Donati, M Kondo, HJ Tochon-Danguy, J-P. Bonjour
Pharmacol., 40, 1469–1475. • 1990

Similar Papers

Loading similar papers…