Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53

  title={Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53},
  author={Kristine Mann and Pierre Hainaut},
The aminothiol WR1065 exerts selective cytoprotective effects in normal cells compared to cancer cells and has clinical applications for the protection of normal cells in cancer patients undergoing radio- or chemotherapy. There is evidence that p53 is activated in response to WR1065. To examine the effects of WR1065 on the signalling pathways controlled by p53, isogeneic human colon carcinoma cell lines (HCT116) differing only in the presence or absence of wild-type p53 were used. Treatment… CONTINUE READING


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Publications referenced by this paper.
Showing 1-9 of 9 references


P Hainaut, K. Mann
Redox Signal., 3, 611–623. • 2001
View 4 Excerpts
Highly Influenced


EJ Lee, M Gerhold, MW Palmer, RD. Christen
J. Cancer, 88, 754–759. • 2003


Y Kataoka, JS Murley, NN Khodarev, RR Weichselbaum, DJ. Grdina
J. Radiat. Oncol. Biol. Phys., 53, 180–189. • 2002


H Shen, ZJ Chen, +3 authors KD. Tew
Pharmacol. Exp. Ther., 297, 1067–1073. • 2001


M Tan, Y Wang, K Guan, Y. Sun
Natl. • 2000


Capizzi RL.
J. Cancer, 32A (Suppl 4), S5–S16. • 1996


R Rainwater, D Parks, ME Anderson, P Tegtmeyer, K. Mann
Cell. Biol., 15, 3892–3903. • 1995

Cancer Chemother

EA Poplin, P LoRusso, +7 authors P. Schein
Pharmacol., 33, 415–419. • 1994


BS Polla, Y Donati, M Kondo, HJ Tochon-Danguy, J-P. Bonjour
Pharmacol., 40, 1469–1475. • 1990

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