Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

  title={Aminosugar derivatives as potential anti-human immunodeficiency virus agents.},
  author={Abraham Karpas and George W J Fleet and Raymond A. Dwek and Sigurdur R Petursson and Sung Keon Namgoong and Nigel Ramsden and Gary S. Jacob and Thomas W. Rademacher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 23},
Recent data suggest that aminosugar derivatives which inhibit glycoprotein processing have potential anti-human immunodeficiency virus (HIV) activity. These inhibitory effects may be due to disruption of cell fusion and subsequent cell-cell transmission of the acquired immunodeficiency syndrome (AIDS) virus. Free virus particles able to bind CD4-positive cells are still produced in the presence of these compounds with only partial reduction of infectivity. We now report a method to score in… CONTINUE READING