Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection

@article{Stefano2013AminosilaneFO,
  title={Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection},
  author={Luca De Stefano and Giorgia Oliviero and Jussara Amato and Nicola Borbone and Gennaro Piccialli and Luciano Mayol and Ivo Rendina and Monica Terracciano and Ilaria Rea},
  journal={Journal of The Royal Society Interface},
  year={2013},
  volume={10}
}
  • Luca De Stefano, Giorgia Oliviero, +6 authors Ilaria Rea
  • Published in
    Journal of The Royal Society…
    2013
  • Biology, Medicine
  • Direct solid phase synthesis of peptides and oligonucleotides (ONs) requires high chemical stability of the support material. In this work, we have investigated the passivation ability of porous oxidized silicon multilayered structures by two aminosilane compounds, 3-aminopropyltriethoxysilane and 3-aminopropyldimethylethoxysilane (APDMES), for optical label-free ON biosensor fabrication. We have also studied by spectroscopic reflectometry the hybridization between a 13 bases ON, directly grown… CONTINUE READING

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