Aminopyrine-N-demethylase I. Directed modification of substrates’ structure as a way of production of inducer of the monooxygenase isoform P-450b

@article{Tsyrlov2010AminopyrineNdemethylaseID,
  title={Aminopyrine-N-demethylase I. Directed modification of substrates’ structure as a way of production of inducer of the monooxygenase isoform P-450b},
  author={L. B. Tsyrlov and K. E. Gerasimov},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={16},
  pages={207-212}
}
SummaryThe effect of the phenobarbital-type monooxygenase inducers is accomplished via the native molecule. This made it possible to transform the typical substrate of cytochrome P-450b aminopyrine into an inducer of this isozyme by blocking the substrate molecule position undergoing monooxygenation. Substitution of two methyl groups in the aminopyrine -N(CH3)2 position by an isopropyl group gave rise to a clear-cut inducive effect This was registered by spectral, kinetic, radiological and… Expand
Aminopyrine-N-demethylase. II. Characterization of a unique monooxygenase isoform P-450ap
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It was, demonstrated that cytochrome P-450ap does not interact with the antibodies to the major phenobarbital induced form, i.e. with cyto chrome P- 450b. Expand
Mitragyna speciosa Korth leaves extracts induced the CYP450 catalyzed aminopyrine-N-demethylase (APND) and UDP-glucuronosyl transferase (UGT) activities in male Sprague-Dawley rat livers
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It is shown that possibilities exist for herb-drug interaction with increased clearance of drugs, which are primarily metabolized by CYP450s and UGT1A6 among M. speciosa leaves extract users. Expand
Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus
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