Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors.

@article{Lundberg1981AminophyllineMS,
  title={Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors.},
  author={D B Lundberg and George R. Breese and Robert A. Mueller},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1981},
  volume={217 1},
  pages={215-21}
}
In intact young rats anesthetized with halothane, aminophylline produces an increase in respiratory minute ventilation due primarily to an increase in respiratory frequency. Although the simulation of respiration by inhalation of 10% CO2 is augmented only at high doses of aminophylline, the response to CO2 is increased at doses as low as 3 mg/kg of aminophylline. Division of the ninth cranial nerve together with removal of the carotid body did not alter the response, whereas vagotomy changed… CONTINUE READING