Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.

@article{Drg2010AminopeptidaseFA,
  title={Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.},
  author={Marcin Drąg and Matthew S Bogyo and Jonathan A Ellman and Guy Salvesen},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 5},
  pages={3310-8}
}
Aminopeptidases process the N-terminal amino acids of target substrates by sequential cleavage of one residue at a time. They are found in all cell compartments of prokaryotes and eukaryotes, being implicated in the major proteolytic events of cell survival, defense, growth, and development. We present a new approach for the fast and reliable evaluation of the substrate specificity of individual aminopeptidases. Using solid phase chemistry with the 7-amino-4-carbamoylmethylcoumarin fluorophore… CONTINUE READING
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Methods Mol. Biol

  • E L Schneider, C S Craik
  • Methods Mol. Biol
  • 2009

Antimicrob. Agents Chemother

  • E Cunningham, M Drag, P Kafarski, A Bell
  • Antimicrob. Agents Chemother
  • 2008

Biochem. J

  • M Drag, J Mikolajczyk, I M Krishnakumar, Z Huang, G S Salvesen
  • Biochem. J
  • 2008

Chem. Biol

  • F Tholander, A Muroya, B P Roques, M C Fournié-Zaluski, M M Thunnissen, J Z Haeggström
  • Chem. Biol
  • 2008

Angew Chem. Int. Ed. Engl

  • A David, D Steer, +5 authors V Dive
  • Angew Chem. Int. Ed. Engl
  • 2007

Bioorg. Med. Chem

  • S Vassiliou, M Xeilari, +4 authors A Mucha
  • Bioorg. Med. Chem
  • 2007

Bioorg. Med. Chem. Lett

  • M Drag, R Grzywa, J Oleksyszyn
  • Bioorg. Med. Chem. Lett
  • 2007

Nat. Protoc

  • A W Patterson, W J Wood, J A Ellman
  • Nat. Protoc
  • 2007

J. Biol. Chem

  • D L Gardiner, K R Trenholme, T S Skinner-Adams, C M Stack, J P Dalton
  • J. Biol. Chem
  • 2006

Nat. Chem. Biol

  • M Bogyo
  • Nat. Chem. Biol
  • 2006

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