Aminopeptidase A inhibitors as potential central antihypertensive agents.

@article{Reaux1999AminopeptidaseAI,
  title={Aminopeptidase A inhibitors as potential central antihypertensive agents.},
  author={Annabelle Reaux and Marie-Claude Fourni{\'e}-Zaluski and C. Bellinger David and Sylvie Zini and B. Roques and Pierre Corvol and C Llorens-cortes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 23},
  pages={
          13415-20
        }
}
Overactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several experimental models, such as spontaneously hypertensive rats and transgenic mice expressing both human renin and human angiotensinogen transgenes. We recently reported that, in the murine brain, angiotensin II (AngII) is converted to angiotensin III (AngIII) by aminopeptidase A (APA), whereas AngIII is inactivated by aminopeptidase N (APN). If injected into… CONTINUE READING
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