Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy.

@article{Kelly2001AminoguanidineAO,
  title={Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy.},
  author={Darren J. Kelly and Richard E Gilbert and Alison J. Cox and T. Soulis and George Jerums and Mark Emmanuel Cooper},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 10},
  pages={2098-107}
}
Profibrotic cytokines and the formation of advanced-glycation end products (AGE) have both been implicated in the pathogenesis of glomerulosclerosis in diabetic kidney disease. However, tubulointerstitial pathology is also an important determinant of progressive renal dysfunction in diabetic nephropathy. This study sought to investigate the expression of profibrotic growth factors and matrix deposition in the glomerulus and the tubulointerstitium and to examine the effect of blocking AGE… CONTINUE READING

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