Aminoguanidine Changes Hippocampal Expression of Apoptosis-Related Genes, Improves Passive Avoidance Learning and Memory in Streptozotocin-Induced Diabetic Rats


Cognitive dysfunction occurs in patients with diabetes mellitus. The objective of this study was to examine whether bilateral intrahippocampal CA1 (intra-CA1) injection of aminoguanidine (AG) can either affect the Bcl-2 family gene expression or reduce the diabetic imposing abnormalities of passive avoidance learning (PAL) and memory. Rats were divided into… (More)
DOI: 10.1007/s10571-013-0018-5


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