Aminoglycosides versus bacteria--a description of the action, resistance mechanism, and nosocomial battleground.

@article{Shakil2008AminoglycosidesVB,
  title={Aminoglycosides versus bacteria--a description of the action, resistance mechanism, and nosocomial battleground.},
  author={Shazi Shakil and Rosina Surovi Khan and Raffaele Zarrilli and Asad U. Khan},
  journal={Journal of biomedical science},
  year={2008},
  volume={15 1},
  pages={5-14}
}
Since 1944, we have come a long way using aminoglycosides as antibiotics. Bacteria also have got them selected with hardier resistance mechanisms. Aminoglycosides are aminocyclitols that kill bacteria by inhibiting protein synthesis as they bind to the 16S rRNA and by disrupting the integrity of bacterial cell membrane. Aminoglycoside resistance mechanisms include: (a) the deactivation of aminoglycosides by N-acetylation, adenylylation or O-phosphorylation, (b) the reduction of the… CONTINUE READING

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