Aminoglycosides in septic shock: an overview, with specific consideration given to their nephrotoxic risk.

@article{Boyer2013AminoglycosidesIS,
  title={Aminoglycosides in septic shock: an overview, with specific consideration given to their nephrotoxic risk.},
  author={Alexandre Boyer and Didier Gruson and St{\'e}phane Bouchet and Benjamin Clouzeau and Bui Hoang-Nam and Fr{\'e}d{\'e}ric Vargas and Hilbert Gilles and Mathi{\'e}u Molimard and Anne Marie Rogues and Nicholas Moore},
  journal={Drug safety},
  year={2013},
  volume={36 4},
  pages={217-30}
}
Aminoglycoside nephrotoxicity has been reported in patients with sepsis, and several risk factors have been described. Once-daily dosing and shorter treatment have reduced nephrotoxicity risk, and simplified aminoglycoside monitoring. This review focuses on nephrotoxicity associated with aminoglycosides in the subset of patients with septic shock or severe sepsis. These patients are radically different from those with less severe sepsis. They may have, for instance, renal impairment due to the… CONTINUE READING
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