Aminoglycosides activate oxygen metabolites production in the cochlea of mature and developing rats

@article{LpezGonzlez1999AminoglycosidesAO,
  title={Aminoglycosides activate oxygen metabolites production in the cochlea of mature and developing rats},
  author={Miguel Angel L{\'o}pez-Gonz{\'a}lez and Francisco Montero Delgado and Miguel Lucas},
  journal={Hearing Research},
  year={1999},
  volume={136},
  pages={165-168}
}
The ototoxicity of antibiotics, particularly of aminoglycosides, is a well-known undesirable side effect which may be based on a free radical mechanism. We studied the effect of different antibiotics in the production of reactive oxygen species in freshly isolated cochleas of mature and 2-10 weeks old developing rats. Phorbol myristate acetate induced the release of reactive oxygen species after a lag time close to 30 s and declined back to basal values in 10-20 min. The rate of reactive oxygen… CONTINUE READING

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