Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat.

@article{Wu2001AminoglycosideOI,
  title={Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat.},
  author={W J Wu and Su-Hua Sha and John D. McLaren and Kohei Kawamoto and Yehoash Raphael and Jochen Schacht},
  journal={Hearing research},
  year={2001},
  volume={158 1-2},
  pages={165-78}
}
The availability of genetic information, transgenic and knock-out animals make the mouse a primary model in biomedical research. Aminoglycoside ototoxicity, however, has rarely been studied in mature mice because they are considered highly resistant to the drugs. This study presents models for kanamycin ototoxicity in adult CBA/J, C57BL/6 and BALB/c mouse strains and a comparison to Sprague-Dawley rats. Five-week-old mice were injected subcutaneously twice daily with 400-900 mg kanamycin base… CONTINUE READING
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