Aminoglycoside-nucleic acid interactions: remarkable stabilization of DNA and RNA triple helices by neomycin.

@article{Arya2001AminoglycosidenucleicAI,
  title={Aminoglycoside-nucleic acid interactions: remarkable stabilization of DNA and RNA triple helices by neomycin.},
  author={Dev P Arya and R. Lane Coffee and Bert Willis and Anna I Abramovitch},
  journal={Journal of the American Chemical Society},
  year={2001},
  volume={123 23},
  pages={5385-95}
}
The stabilization of poly(dA).2poly(dT) triplex, a 22-base DNA triplex, and poly(rA).2poly(rU) triple helix by neomycin is reported. The melting temperatures, the association and dissociation kinetic parameters, and activation energies (E(on) and E(off)) for the poly(dA).2poly(dT) triplex in the presence of aminoglycosides and other triplex binding ligands were determined by UV thermal analysis. Our results indicate that: (i) neomycin stabilizes DNA triple helices, and the double helical… CONTINUE READING
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