Aminoglycoside-induced blockade of reflex activity in the isolated spinal cord from the neonatal rat.


The subarachnoid injection of gentamicin into rats causes a transient flaccid paralysis of the hindlimbs lasting 1 to 5 hrs followed by a permanent flaccid paralysis which develops after 24 to 36 hrs. Although the early transient paralysis could be attributed to a pharmacologic blockade of central synaptic transmission, the mechanism of the blockade was not… (More)


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