Aminoglycoside dosages and nephrotoxicity: quantitative relationships.

  title={Aminoglycoside dosages and nephrotoxicity: quantitative relationships.},
  author={Florent Rougier and Michel Ducher and Michel Maurin and St{\'e}phane Corvaisier and Daniel Claude and Roger W. Jelliffe and Pascal Maire},
  journal={Clinical pharmacokinetics},
  volume={42 5},
OBJECTIVE To develop a model that relates the probability of occurrence of nephrotoxicity to the cumulative area under the curve (AUC) of amikacin serum concentration. DESIGN AND PATIENTS This was a retrospective study of two groups of patients in whom nephrotoxicity was observed after administration of amikacin. The first group consisted of patients treated with once-daily administration (ODA) [n = 13]. The second group consisted of patients treated with twice-daily administration (TDA) [n… CONTINUE READING
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