Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes.

@article{Au1987AminoglycosideAP,
  title={Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes.},
  author={S. Au and N. D. Weiner and J. Schacht},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={902 1},
  pages={
          80-6
        }
}
  • S. Au, N. D. Weiner, J. Schacht
  • Published 1987
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The rate of release from multilamellar liposomes of the fluorescent probe carboxyfluorescein was determined as a measure of membrane permeability. Liposomes of phosphatidylcholine and different anionic phospholipids were incubated with low (1 microM) and high (3 mM) concentrations of calcium in the absence or presence of aminoglycoside antibiotics. The leakage of carboxyfluorescein into the medium was not caused by liposomal fusion as no vesicle fusion was observed in experiments with terbium… CONTINUE READING
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