Aminoglycoside antibiotics induce bacterial biofilm formation

@article{Hoffman2005AminoglycosideAI,
  title={Aminoglycoside antibiotics induce bacterial biofilm formation},
  author={Lucas R. Hoffman and David A. D'Argenio and Michael J. MacCoss and Zhaoying Zhang and Roger A. Jones and Samuel I. Miller},
  journal={Nature},
  year={2005},
  volume={436},
  pages={1171-1175}
}
Biofilms are adherent aggregates of bacterial cells that form on biotic and abiotic surfaces, including human tissues. Biofilms resist antibiotic treatment and contribute to bacterial persistence in chronic infections. Hence, the elucidation of the mechanisms by which biofilms are formed may assist in the treatment of chronic infections, such as Pseudomonas aeruginosa in the airways of patients with cystic fibrosis. Here we show that subinhibitory concentrations of aminoglycoside antibiotics… CONTINUE READING
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