Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.

Abstract

Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.

DOI: 10.1039/c2mb25333j

Cite this paper

@article{Kim2012AminoglycosideAB, title={Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.}, author={Henna Kim and Mi-Kyung Lee and Junsang Ko and Chin-Ju Park and Meehyein Kim and Yujeong Jeong and Sungwoo Hong and Gabriele Varani and Byong-Seok Choi}, journal={Molecular bioSystems}, year={2012}, volume={8 11}, pages={2857-9} }