Aminoglutethimide dose and hormone suppression in advanced breast cancer.

  title={Aminoglutethimide dose and hormone suppression in advanced breast cancer.},
  author={Adrian L. Harris and Mitchell Dowsett and S. L. Jeffcoate and Ian E. Smith},
  journal={European journal of cancer & clinical oncology},
  volume={19 4},
The effect of the dose of aminoglutethimide on the suppression of oestrone, oestradiol and dehydroepiandrosterone sulphate (DHAS) levels was studied in 36 women with advanced postmenopausal breast cancer, all of whom received 20 mg hydrocortisone twice daily as replacement glucocorticoid. Aminoglutethimide (AG) 250 mg twice a day was as effective as AG 250 mg 3 times a day or AG 250 mg 4 times a day. Side-effects were less at the lowest dosage and were age-related. On-treatment oestrone levels… CONTINUE READING