Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

@article{Arajo2018AminochromeDN,
  title={Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.},
  author={Fillipe M de Ara{\'u}jo and Rafael Sales Medina Ferreira and Cleide S Souza and Cleonice Creusa Dos Santos and T{\'a}cio L R S Rodrigues and Juliana Helena C E Silva and Juciano Gasparotto and Daniel Pens Gelain and Ramon dos Santos El-Bach{\'a} and Maria de F{\'a}tima D Costa and Jos{\'e} Claudio M Fonseca and Juan Segura-Aguilar and S{\'i}lvia Lima Costa and Victor Diogenes Amaral Silva},
  journal={Neurotoxicology},
  year={2018},
  volume={66},
  pages={
          98-106
        }
}
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction of proteasomal and lysosomal systems, endoplasmic reticulum stress and disruption of the microtubule network, but until now there has been no evidence of effects on production of cytokines and neurotrophic factors, that are mechanisms involved in… CONTINUE READING
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