Aminocarbonylation of aryl tosylates to carboxamides.

Abstract

The palladium - catalyzed aminocarbonylation of aryl tosylates with amines is reported. Suitable conditions were identified by high throughput reaction screening and then further optimized. The substrate scope of the reaction with respect to the aryl tosylate component and the amine component are reported. Competitive aminolysis of the aryl tosylates to… (More)
DOI: 10.1021/acs.orglett.5b01283

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Cite this paper

@article{Chung2015AminocarbonylationOA, title={Aminocarbonylation of aryl tosylates to carboxamides.}, author={Seungwon Chung and Neal W. Sach and Chulho Choi and Xiaojing Yang and Susan E Drozda and Robert A. Singer and Stephen W. Wright}, journal={Organic letters}, year={2015}, volume={17 11}, pages={2848-51} }