Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients

@article{Cabillic2010AminobisphosphonatepretreatedDC,
  title={Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients},
  author={Florian Cabillic and Olivier Toutirais and Vincent Lavou{\'e} and C{\'e}cile Thomas de la Pinti{\`e}re and P. Gelman Daniel and Nathalie Rioux-Leclerc and Bruno Turlin and Hannu M{\"o}nkk{\"o}nen and Jukka M{\"o}nkk{\"o}nen and Karim Boudjema and V{\'e}ronique Catros and Françoise Bouet-Toussaint},
  journal={Cancer Immunology, Immunotherapy},
  year={2010},
  volume={59},
  pages={1611-1619}
}
Hepatocellular carcinoma (HCC) and colorectal carcinoma with hepatic metastases (mCRC) are cancers with poor prognosis and limited therapeutic options. New approaches are needed and adoptive immunotherapy with Vγ9Vδ2 T lymphocytes represents an attractive strategy. Indeed, Vγ9Vδ2 T cells were shown to exhibit efficient lytic activity against various human tumor cell lines, and in vitro Vγ9Vδ2 T expansion protocol based on single phosphoantigen stimulation could be easily performed for healthy… CONTINUE READING

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