Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo

@article{Endo1993AminoalkylbisphosphonatesPI,
  title={Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo},
  author={Yasuo Endo and Masanori Nakamura and Takashi Kikuchi and Hisashi Shinoda and Yoshikazu Takeda and Yasutaka Nitta and Katsuo Kumagai},
  journal={Calcified Tissue International},
  year={1993},
  volume={52},
  pages={248-254}
}
Aminoalkyl derivatives of bisphosphonates are potent inhibitors of bone resorption. A single I.P. injection of 4-amino-1-hydroxybutylidene-1,1-bis-phosphonate (AHBuBP) induced a prolonged enhancement of histidine decarboxylase (HDC) activity in the bone marrow, spleen, lung, and liver of mice and resulted in an increase in histamine. The induction of HDC by the agent was dose dependent (16–80 μmol/kg) and peaked 3–4 days after its injection (40 μmol/kg). Repeated S.C. injections of smaller… CONTINUE READING