Aminoacylation of hypomodified tRNAGlu in vivo.

  title={Aminoacylation of hypomodified tRNAGlu in vivo.},
  author={M K Kr{\"u}ger and Michael Askvad S\orensen},
  journal={Journal of molecular biology},
  volume={284 3},
The highly specific interaction of each aminoacyl-tRNA synthetase and its substrate tRNAs constitutes an intriguing problem in protein-RNA recognition. All tRNAs have the same overall three-dimensional structure in order to fit interchangeably into the translational apparatus. Thus, the recognition by aminoacyl-tRNA synthetase must be more or less limited to discrimination between bases at specific positions within the tRNA. The hypermodified nucleotide 5-methylaminomethyl-2-thiouridine… CONTINUE READING