Aminoacylation of RNA minihelices with alanine

@article{Francklyn1989AminoacylationOR,
  title={Aminoacylation of RNA minihelices with alanine},
  author={Christopher Francklyn and Paul R. Schimmel},
  journal={Nature},
  year={1989},
  volume={337},
  pages={478-481}
}
The genetic code is determined by both the specificity of the triplet anticodon of tRNAs for codons in mRNAs and the specificity with which tRNAs are charged with amino acids. The latter depends on interactions between tRNAs and their charging enzymes, and an advance in understanding such interactions was provided recently by the demonstration that a major determinant of the identity of alanine tRNA is located in the amino-acid acceptor helix. Multiple substitutions in many distinct parts of… CONTINUE READING
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