Aminoacyl-tRNA synthetases: a new image for a classical family.

  title={Aminoacyl-tRNA synthetases: a new image for a classical family.},
  author={Susan A. Martinis and Pierre Plateau and Jean Cavarelli and Catherine Florentz},
  volume={81 7},
The aminoacyl-tRNA synthetases (aaRSs) are a family of enzymes well known for their role in protein synthesis. More recent investigations have discovered that this classic family of enzymes is actually capable of a broad repertoire of functions which not only impact protein synthesis, but extend to a number of other critical cellular activities. Specific aaRSs play roles in cellular fidelity, tRNA processing, RNA splicing, RNA trafficking, apoptosis, transcriptional and translational regulation… CONTINUE READING