Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

@article{Almind1993AminoacidPO,
  title={Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.},
  author={Katrine Almind and Christian Bj\orbaek and Henrik Vestergaard and Torben Hansen and S\oren M. Echwald and Oluf Pedersen},
  journal={Lancet},
  year={1993},
  volume={342 8875},
  pages={828-32}
}
Since relative or absolute insulin deficiency and insulin insensitivity are involved in the aetiology of non-insulin-dependent diabetes mellitus (NIDDM), we examined whether patients with NIDDM exhibit genetic variability in the coding region of insulin receptor substrate-1 (IRS-1), a candidate gene that is ubiquitous in insulin-sensitive and insulin-like growth factor 1 (IGF1) sensitive tissues, including those that determine glucose production and clearance and those with regulatory effects… CONTINUE READING

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