Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.

@article{Sharma2009AminoacetoneAT,
  title={Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.},
  author={Vasudha Sharma and Gilbert T Kelly and Jennifer Foulke-Abel and C. Watanabe},
  journal={Organic letters},
  year={2009},
  volume={11 17},
  pages={
          4006-9
        }
}
Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B… Expand

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