Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: High interspecies homology

@article{Huber2004AminoterminalSO,
  title={Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: High interspecies homology},
  author={Daniel Huber and P Gautschi-Sova and Peter Böhlen},
  journal={Neurochemical Research},
  year={2004},
  volume={15},
  pages={435-439}
}
Recently, the partial structural characterization of a novel bovine brain protein was reported (1). Because of its mitogenic activity for vascular endothelial cells and its ability to strongly bind heparin it was termed heparin-binding brain mitogen (HBBM). Although HBBM shares these properties with members of the fibroblast growth factor (FGF) family of growth factors, its aminoterminal sequence is not homologous to that of the FGFs. Now, we report the isolation and partial structural… 
4 Citations
The potential role of the heparin-binding growth factor pleiotrophin in breast cancer
TLDR
It is proposed that PTN has the potential to support growth of breast cancer at its primary site and to enhance the ability of tumor cells to metastasize and that understanding the functions of PTN and its hormonal regulation can lead to the development of novel therapeutic strategies for breast cancer.
Molecular and pharmacologic targeting of angiogenesis factors — the example of pleiotrophin
TLDR
Different approaches to inhibit production and function of the heparinbinding growth factor pleiotrophin are presented and how the experience from this growth factor can be applied to improve the role of other factors thought to contribute to tumor angiogenesis is discussed.
Atlas of Genetics and Cytogenetics in Oncology and Haematology PTN ( pleiotrophin )
TLDR
The name pleiotrophin is widely accepted nowadays and reflects the plethora of functions it exerts in different tissues and cell l ines (see "Function").
Growth factor targeted and conventional therapy of breast cancer
  • A. Wellstein
  • Biology, Medicine
    Breast Cancer Research and Treatment
  • 2004
TLDR
Different therapeutic approaches that take advantage of paracrine signals to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass are discussed with respect to their interaction with conventional therapies of breast cancer.

References

SHOWING 1-10 OF 20 REFERENCES
An 18‐kd heparin‐binding protein of developing brain that is distinct from fibroblast growth factors.
TLDR
The properties of p18 suggest that it has a role in the growth and maturation of brain and is immunochemically distinct from the basic fibroblast growth factor.
Chemical and biological characterization of a truncated form of acidic fibroblast growth factor from bovine brain.
Two forms of acidic fibroblast growth factor were isolated from bovine brain by a combination of ammonium sulfate precipitation, cation-exchange chromatography, heparin-Sepharose affinity
Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies.
TLDR
The complete amino acid sequence of aFGF has been determined and observed to be similar to both basic FGF and interleukin-1's and a neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aF GF sequence.
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.
  • F. Esch, A. Baird, R. Guillemin
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
TLDR
The two major mitogenic polypeptides for endothelial cells have been purified to homogeneity and the available protein sequence data demonstrate the existence of significant structural homology between the two polyPEptides.
Amino acid sequence of human acidic fibroblast growth factor.
Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.
TLDR
The high specific mitogenic activity for endothelial cells, high affinity for heparin and cross‐reactivity with antibodies against bovinebasic FGF (bFGF) suggest a relationship of those materials with basic FGF, and suggest that the sequence of aFGF is highly conserved among vertebrates.
The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.
TLDR
Several experiments strongly suggested that FGF-5 is a growth factor with properties common to those of acidic and basic FGFs, and this oncogene is the fifth documented protein related to fibroblast growth factors (FGFs).
Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.
Brain and pituitary fibroblast growth factors (FGF) have been purified to apparent homogeneity from crude tissue extracts by a three-step procedure, including salt precipitation, ion-exchange
Isolation and partial molecular characterization of pituitary fibroblast growth factor.
Fibroblast growth factor (FGF) has been purified to homogeneity from bovine pituitaries by two methods. Starting material for both methods was an FGF preparation partially purified as described by
...
...