Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.

@article{Greenberg1995AminoterminalRO,
  title={Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.},
  author={Steven A. Greenberg and Wei Qiao Qiu and Dennis J Selkoe and A Ben-Itzhak and Kenneth S. Kosik},
  journal={Neuroscience letters},
  year={1995},
  volume={198 1},
  pages={52-6}
}
The secreted form of the beta-amyloid precursor protein (beta-APP) has previously been shown to stimulate mitogen-activated protein (MAP) kinases in PC-12 pheochromocytoma cells. The amino-terminal half of secreted beta-APP contains a region rich in cysteine residues reminiscent of cysteine-rich binding regions in other families of extracellular proteins. We found that reductive alkylation of disulfide linkages eliminated the ability of secreted beta-APP to activate MAP kinase. To confirm the… CONTINUE READING

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