Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

@article{Nobukuni2005AminoAM,
  title={Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.},
  author={Takahiro Nobukuni and Manel Joaquin and Marta Roccio and Stephen G Dann and So Young Kim and Pawan Gulati and Maya P Byfield and Jonathan M. Backer and Francois Natt and J. L. Bos and Fried J. T. Zwartkruis and George Thomas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 40},
  pages={14238-43}
}
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathway to control the growth and development of the organism. Insulin regulates mTOR function through a recently described canonical signaling pathway, which is initiated by the activation of class 1 PI3K. However, how the amino acid input is integrated… CONTINUE READING
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