Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation.

@article{Chang2001AminoAI,
  title={Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation.},
  author={Wenhan Chang and Stacy A Pratt and T H Chen and Lilly Y. W. Bourguignon and Dolores Marie Shoback},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 47},
  pages={44129-36}
}
The C-terminal tail of the calcium receptor (CaR) regulates the affinity of the receptor for ligand, desensitization, and membrane localization. To determine the role of specific amino acids in the bovine parathyroid CaR in mediating signal transduction and cell-surface expression, we transfected truncated and mutated CaR cDNAs into HEK-293 cells. The ability of high extracellular [Ca(2+)] ([Ca(2+)](o)) to increase total inositol phosphate (InsP) production, an index of phospholipase C (PLC… CONTINUE READING

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