Amino acids in healthy aging skeletal muscle.

  title={Amino acids in healthy aging skeletal muscle.},
  author={Emily S. Riddle and Martha H Stipanuk and Anna E Thalacker-Mercer},
  journal={Frontiers in bioscience},
Life expectancy in the U.S. and globally continues to increase. Despite increased life expectancy quality of life is not enhanced, and older adults often experience chronic age-related disease and functional disability, including frailty. Additionally, changes in body composition such as the involuntary loss of skeletal muscle mass (i.e. sarcopenia) and subsequent increases in adipose tissue can augment disease and disability in this population. Furthermore, increased oxidative stress and… Expand
Dietary protein supplementation in the elderly for limiting muscle mass loss
Overall, it appears that an intake of approximately 0.2–1.6 g protein/kg BW/day may be recommended taking into account potential anabolic resistance, suggesting that an optimal protein consumption may represent an important parameter to preserve independence and contribute to health status in the elderly. Expand
Muscle Building and Maintenance in the Elderly: the Use of Protein
This chapter focuses on the key factors impacting muscle protein synthesis in the elderly including adequacy of total caloric intake, a focus on the total daily quantity of high quality protein, a balanced pattern of protein ingestion per meal, characteristics regarding protein quality, anabolic resistance of aging, and achieving anadequacy of the essential amino acid, leucine, in each meal. Expand
Metabolomic profiles of being physically active and less sedentary: a critical review.
Several metabolic pathways were associated with higher PA and fitness and less sedentary time, including tricarboxylic acid cycle, glycolysis, aminoacyl-tRNA biosynthesis, urea cycle, arginine biosynthesis), branch-chain amino acids, and estrogen metabolism. Expand
Higher vegetable protein consumption, assessed by an isoenergetic macronutrient exchange model, is associated with a lower presence of overweight and obesity in the web-based Food4me European study
As success rates on reducing overweight/obesity are very low, form a public health perspective, the elaboration of policies for increasing intakes of vegetable protein and reducing animal protein and sugars, may be a method of combating overweight/OBesity at a population level. Expand
Composition of free and peptide-bound amino acids in beef chuck, loin, and round cuts.
This is the first study to determine aspartate, asparagine, glutamate, and glutamine in meat proteins of any animal species and the findings may help guide future decisions regarding human and animal nutrition. Expand
Dairy protein, exercise and inflammatory markers in older adults


Effects of Aging on Muscle Fibre Type and Size
Given the demographic trends evident in most western societies, i.e. increased number of those considered aged, management interventions for sarcopenia must become a major goal of the healthcare profession. Expand
Sarcopenia, weight loss, and nutritional frailty in the elderly.
Clinical interventions for weight loss, sarcopenia, and cytokine alterations have been used with modest success, and the multiple causes of nutritional frailty are not completely understood. Expand
Invited review: Aging and sarcopenia.
  • T. Doherty
  • Biology, Medicine
  • Journal of applied physiology
  • 2003
The link between sarc Openia and disability among elderly men and women highlights the need for continued research into the development of the most effective interventions to prevent or at least partially reverse sarcopenia, including the role of resistance exercise and other novel pharmacological and nutritional interventions. Expand
Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging.
The beneficial effects of F1 are demonstrated to attenuate loss of muscle mass associated with aging and to alleviate/delay age-specific changes in skeletal muscles. Expand
Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia.
Preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia, which could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability. Expand
Basal muscle amino acid kinetics and protein synthesis in healthy young and older men.
Differences in basal muscle protein turnover between older and younger men do not appear to explain muscle loss that occurs with age. Expand
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle.
A novel stable isotope technique was developed to measure in vivo rates of mitochondrial protein synthesis in human skeletal muscle using needle biopsy samples and this technique was applied to elucidate a potential mechanism for the age-related decline in the mitochondrial content and function of skeletal muscle. Expand
Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults.
Essential amino acids are primarily responsible for the amino acid-induced stimulation of muscle protein anabolism in the elderly. Expand
Age-related changes in glutathione availability and skeletal muscle carbonyl content in healthy rats
Although tissue glutathione content decreased with age, the other markers of oxidative stress were little changed during aging and the stability of skeletal muscle carbonyl content during aging suggests a very efficient degradation of oxidized proteins in muscle. Expand
Decline in skeletal muscle mitochondrial function with aging in humans.
  • K. Short, M. Bigelow, +4 authors K. Nair
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
It is demonstrated that age-related muscle mitochondrial dysfunction is related to reduced mtDNA and muscle functional changes that are common in the elderly, supporting the oxidative damage theory of aging. Expand