Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders
@article{Meldrum1993AminoAA,
title={Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders},
author={Brian S. Meldrum},
journal={Brain Research Reviews},
year={1993},
volume={18},
pages={293-314}
}126 Citations
The role of excitotoxicity in neurodegenerative disease: implications for therapy.
- Biology, MedicinePharmacology & therapeutics
- 1999
Oxidative stress, glutamate, and neurodegenerative disorders.
- Biology, PsychologyScience
- 1993
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
The Role of Excitatory Aminoacids and its Neurotoxic Impact in Severe Head Injury Patients
- Medicine, Biology
- 2011
The impact on enzyme activities shows a clear sign on the affect of cardial enzymes due to severe head injury, which may be of vital importance in treating patients with antagonists in suppressing the levels of glutamic and aspartic acids.
A Review of Glutamate Receptors II: Pathophysiology and Pathology
- Biology
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The diseases in which the pathophysiology and pathology are associated, in part, with the glutamate system are explored, including epilepsy, amnesia, anxiety, hyperalgesia and psychosis.
Excitatory Amino Acids and Neurotoxicity in the Human Neocortex
- Biology
- 1995
The current review focuses on the role of EAAs as neurotransmitters within particular pathways of the human cortex, particularly with regard to the neocortex and comparisons with data from non-human primates.
Homocysteine induces cell death of rat astrocytes in vitro
- Biology, MedicineNeuroscience Letters
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Therapeutic Potential of AMPA Receptor Ligands in Neurological Disorders
- Biology
- 1996
Recent evidence suggests that antagonists at non-NMDA receptors are more effective neuroprotective agents than NMDA receptor antagonists after ischaemic attacks, and that their administration can be delayed for up to 12 hours without seriously compromising the extent of neuroprotection.
Delayed Excitotoxic Neurodegeneration Induced by Excitatory Amino Acid Agonists in Isolated Retina
- BiologyJournal of neurochemistry
- 1995
It is shown that glutamate, NMDA, AMPA, and KA all cause delayed as well as acute excitotoxic damage in the retina, and brief exposure to the non‐NMDA receptor agonists, in relatively low concentrations, led to delayed LDH release.
Glutamate as a neurotransmitter in the brain: review of physiology and pathology.
- BiologyThe Journal of nutrition
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Endogenous glutamate, by activating NMDA, AMPA or mGluR1 receptors, may contribute to the brain damage occurring acutely after status epilepticus, cerebral ischemia or traumatic brain injury, and may also contribute to chronic neurodegeneration in such disorders as amyotrophic lateral sclerosis and Huntington's chorea.
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