Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders

@article{Meldrum1993AminoAA,
  title={Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders},
  author={Brian S. Meldrum},
  journal={Brain Research Reviews},
  year={1993},
  volume={18},
  pages={293-314}
}
  • B. Meldrum
  • Published 1 September 1993
  • Biology, Medicine
  • Brain Research Reviews
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TLDR
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Glutamate as a neurotransmitter in the brain: review of physiology and pathology.
TLDR
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If defective mitochondrial energy metabolism plays a role in cell death in neurodegenerative disorders, potential therapeutic strategies would be to use excitatory amino acid antagonists or agents to bypass bioenergetic defects.
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The results raise the possibility that a regional impairment of intracellular energy metabolism may secondarily result in excitotoxic neuronal death in chronic neurodegenerative illnesses, such as Huntington's disease.
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