Amino acids as cryoprotectants for liposomal delivery systems.

  title={Amino acids as cryoprotectants for liposomal delivery systems.},
  author={Afzal R Mohammed and Allan G. A. Coombes and Yvonne Perrie},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={30 5},
Liposomes provide an efficient delivery system for solubilisation and delivery of both small and macro molecules. However, they suffer from the disadvantage of instability when stored as aqueous dispersions. Cryoprotection of the liposomal systems provides an effective approach to overcome poor stability whilst maintaining formulation characteristics, although, the formulation of a freeze-dried product requires the consideration of not only the selection of an appropriate cryoprotectant, but… CONTINUE READING

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