Amino acids and the brain: do they play a role in "central fatigue"?

@article{Meeusen2007AminoAA,
  title={Amino acids and the brain: do they play a role in "central fatigue"?},
  author={Romain Meeusen and Philip Watson},
  journal={International journal of sport nutrition and exercise metabolism},
  year={2007},
  volume={17 Suppl},
  pages={
          S37-46
        }
}
  • R. Meeusen, P. Watson
  • Published 1 February 2007
  • Biology
  • International journal of sport nutrition and exercise metabolism
It is clear that the cause of fatigue is complex, influenced by both events occurring in the periphery and the central nervous system (CNS). It has been suggested that exercise-induced changes in serotonin (5-HT), dopamine (DA), and noradrenaline (NA) concentrations contribute to the onset of fatigue during prolonged exercise. Serotonin has been linked to fatigue because of its documented role in sleep, feelings of lethargy and drowsiness, and loss of motivation, whereas increased DA and NA… 
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