Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections

  title={Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections},
  author={Linda S. Sorkin and David J. McAdoo},
  journal={Brain Research},

Periaqueductal gray matter glutamate and GABA decrease following subcutaneous formalin injection in rat.

It is shown that, in vivo, a nociceptive stimulation may activate opioidergic fibres into the PAG and the increased release of endogenous opioids may, in turn, inhibit the activity of the GABAergic neurons.

State-dependent changes in glutamate, glycine, GABA, and dopamine levels in cat lumbar spinal cord.

It is suggested that the reciprocal changes in the release of glutamate, glycine, and GABA versus dopamine during REM sleep contribute to the reduction of sensory inflow to higher brain centers via the dorsal spinocerebellar tract and nearby SRT during this behavioral state.

Formalin-induced spinal glutamate release in freely moving rats: comparison of two spinal microdialysis approaches.

The loop probe technique in CSF is more reproducible for routine investigation of drug effects, whereas the microdialysis of the dorsal horn provides a useful tool to precisely locate where the release of the neurotransmitters occurs.

Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat.

It is argued that supramaximal doses of intrathecal remifentanil sufficient to inhibit phase 1 activity still permitted sufficient glutamate release to allow spinal facilitation, and complete suppression of spinal excitatory neurotransmitter release by intrathecally administered opioids is consistent with spinal wind-up that is triggered during phase 1 and results in phase 2 afferent drive.



Release of norepinephrine and serotonin in cat spinal cord: direct in vivo evidence for the activation of descending monoamine pathways by somatic stimulation.

The results suggest that the activation of small diameter, peripheral somatic, afferents activates descending monoamine pathways and one consequence of this activation, as predicted by the effects of the intrathecal administration of these monoamines, would be to modulate the processing of nociceptive information.

Monoamine release from cat spinal cord by somatic stimuli: an intrinsic modulatory system.

The results suggest the existence of a spinopetal monoamine system which is activated by peripheral stimuli and the modulatory influence associated with increasing monoamine tone in the spinal cord clearly indicated that somatic stimuli may activate a descending monoamine pathway which serves to modulate the magnitude of the ascending sensory message.

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

  • L. AanonsenG. Wilcox
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1987
The results suggest that the actions of EAAs in the spinal cord are differentially affected by various opioid phencyclidine, sigma and adrenergic receptor agonists and support the hypothesis that EAAs are involved in the transmission of nociceptive information inThe spinal cord.