Amino acids and mTOR signalling in anabolic function.

@article{Proud2007AminoAA,
  title={Amino acids and mTOR signalling in anabolic function.},
  author={Christopher G Proud},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={
          1187-90
        }
}
Amino acids regulate signalling through the mTORC1 (mammalian target of rapamycin, complex 1) and thereby control a number of components of the translational machinery, including initiation and elongation factors. mTORC1 also positively regulates other anabolic processes, in particular ribosome biogenesis. The most effective single amino acid is leucine. A key issue is how intracellular amino acids regulate mTORC1. This does not require the TSC1/2 (tuberous sclerosis complex 1/2) complex, which… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 72 CITATIONS, ESTIMATED 55% COVERAGE

Leucine in Obesity: Therapeutic Prospects.

  • Trends in pharmacological sciences
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

High Calorie Diet and the Human Brain

  • Springer International Publishing
  • 2015

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

Translational Control of Gene Expression (Sonenberg, N., Hershey, J.W.B. and Mathews, M.B., eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor

O. Meyuhas, E. Hornstein
  • Prog. Mol. Subcell. Biol
  • 2001