Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells.

@article{Xu2012AminoA4,
  title={Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells.},
  author={Chen Xu and Wei-Bin Hu and Ke Xu and Yun-Xia He and Tong-Yan Wang and Ze Chen and Tian-xian Li and Jin-hua Liu and Philippe Buchy and Bing Sun},
  journal={The Journal of general virology},
  year={2012},
  volume={93 Pt 3},
  pages={531-40}
}
It has been reported that the avian-origin influenza A virus PB1 protein (avian PB1) enhances influenza A virus polymerase activity in mammalian cells when it replaces the human-origin PB1 protein (human PB1). Characterization of the amino acid residues that contribute to this enhancement is needed. In this study, it was found that PB1 from an avian-origin influenza A virus [A/Cambodia/P0322095/2005, H5N1 (Cam)] could enhance the polymerase activity of an attenuated human isolated virus, A/WSN… CONTINUE READING

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Confirmed Human Cases of Avian Influenza (H5N1)

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