Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.

@article{Kammerer2003AminoAV,
  title={Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.},
  author={Stefan Kammerer and Lora L Burns-Hamuro and Yuliang Ma and Sara C. Hamon and Jaume M. Canaves and Michael M Shi and Matthew R. Nelson and Charles F. Sing and Charles R. Cantor and Susan S. Taylor and Andreas Braun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 7},
  pages={4066-71}
}
The focus of human genetics in recent years has shifted toward identifying genes that are involved in the development of common diseases such as cancer, diabetes, cardiovascular diseases, and Alzheimer's disease. Because many complex diseases are late-onset, the frequencies of disease susceptibility alleles are expected to decrease in the healthy elderly individuals of the population at large because of their contribution to disease morbidity andor mortality. To test this assumption, we… CONTINUE READING
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