Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

@article{Fuchs2005AminoAT,
  title={Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?},
  author={B. Fuchs and B. Bode},
  journal={Seminars in cancer biology},
  year={2005},
  volume={15 4},
  pages={
          254-66
        }
}
Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the "tumor metabolome". Each has recently been shown to play important roles in the growth and survival of cancer cell lines, making them potential targets for cancer therapy. The properties and putative relationship of these two amino acid exchangers are discussed in the context… Expand
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