Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

@article{Mok2014AminoAS,
  title={Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.},
  author={Chris Ka Pun Mok and Horace Hok Yeung Lee and Maxime Lestra and John Malcolm Nicholls and Michael Chi Wai Chan and Sin Fun Sia and Huachen Maria Zhu and Leo Lit Man Poon and Yi Guan and Joseph Sriyal Malik Peiris},
  journal={Journal of virology},
  year={2014},
  volume={88 6},
  pages={3568-76}
}
UNLABELLED A novel avian-origin influenza A/H7N9 virus emerged in 2013 to cause more than 130 cases of zoonotic human disease, with an overall case fatality rate of around 30% in cases detected. It has been shown that an E-to-K amino acid change at residue 627 of polymerase basic protein 2 (PB2) occurred frequently in the H7N9 isolates obtained from humans but not in viruses isolated from poultry. Although this mutation has been reported to confer increased mammalian pathogenicity in other… CONTINUE READING
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