Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program.

@article{Tattoli2012AminoAS,
  title={Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program.},
  author={Ivan Tattoli and Matthew T. Sorbara and Dajana Vuckovic and Arthur Ling and Fraser Soares and Let{\'i}cia A. M. Carneiro and Chloe Yang and Andrew Emili and Dana J Philpott and Stephen E. Girardin},
  journal={Cell host & microbe},
  year={2012},
  volume={11 6},
  pages={563-75}
}
Autophagy, which targets cellular constituents for degradation, is normally inhibited in metabolically replete cells by the metabolic checkpoint kinase mTOR. Although autophagic degradation of invasive bacteria has emerged as a critical host defense mechanism, the signals that induce autophagy upon bacterial infection remain unclear. We find that infection of epithelial cells with Shigella and Salmonella triggers acute intracellular amino acid (AA) starvation due to host membrane damage… CONTINUE READING
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