Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.

@article{Mann1989AminoAS,
  title={Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.},
  author={Karlheinz Mann and Rainer Deutzmann and Monique Aumailley and Rupert Timpl and Laura Raimondi and Yukio Yamada and T C Pan and D. E. Conway and Mon Li Chu},
  journal={The EMBO journal},
  year={1989},
  volume={8 1},
  pages={65-72}
}
The whole amino acid sequence of nidogen was deduced from cDNA clones isolated from expression libraries and confirmed to approximately 50% by Edman degradation of peptides. The protein consists of some 1217 amino acid residues and a 28-residue signal peptide. The data support a previously proposed dumb-bell model of nidogen by demonstrating a large N-terminal globular domain (641 residues), five EGF-like repeats constituting the rod-like domain (248 residues) and a smaller C-terminal globule… CONTINUE READING

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