Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker.

@article{Patton1992AminoAR,
  title={Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker.},
  author={D E Patton and J. W. West and William A. Catterall and Alan L. Goldin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 22},
  pages={10905-9}
}
The cytoplasmic linker connecting domains III and IV of the voltage-gated Na+ channel is thought to be involved in fast inactivation. This linker is highly conserved among the various Na+ channels that have been cloned. In the rat brain IIA Na+ channel, it consists of 53 amino acids of which 15 are charged. To investigate the role of this linker in inactivation, we mutated all 15 of the charged residues in various combinations. All but one of these mutants expressed functional channels, and all… CONTINUE READING

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