Amino acid residues on human poliovirus receptor involved in interaction with poliovirus.

@article{Aoki1994AminoAR,
  title={Amino acid residues on human poliovirus receptor involved in interaction with poliovirus.},
  author={Junken Aoki and Satoshi Koike and Iku Ise and YASUKO SATO-YOSHIDA and A. Nomoto},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 11},
  pages={8431-8}
}
We have previously demonstrated that the N-terminal immunoglobulin-like domain (domain 1; 115 amino acids) of human poliovirus receptor (hPVR) is essential for poliovirus binding and infection to cells. To identify amino acids involved in the interaction with poliovirus, we constructed a number of cDNAs encoding mutant hPVRs whose domain 1 was partially derived from mouse PVR (mPVR) homolog, which does not serve as a binding site for poliovirus. Poliovirus binding and infection assays were… CONTINUE READING

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