Amino acid residue 104 in an alpha-class glutathione S-transferase is essential for the high selectivity and specificity of the enzyme for 4-hydroxynonenal.

@article{Nanduri1996AminoAR,
  title={Amino acid residue 104 in an alpha-class glutathione S-transferase is essential for the high selectivity and specificity of the enzyme for 4-hydroxynonenal.},
  author={Bindu Nanduri and James B. Hayden and Yogesh C. Awasthi and Piotr Zimniak},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={335 2},
  pages={305-10}
}
Murine mGSTA4-4 is a glutathione S-transferase with high activity and specificity for products of lipid peroxidation, including the cytotoxic 4-hydroxynonenal (4-HNE). Physiological relevance of this enzyme in the defense against effects of oxidative stress can be inferred from the above biochemical properties, and has been also directly demonstrated by us… CONTINUE READING